Thrombocytopenia in Experimental Trypanosomiasis
نویسندگان
چکیده
منابع مشابه
Thrombocytopenia in experimental trypanosomiasis.
The effect of experimental trypanosomiasis on coagulation was studied because a patient in this hospital with Rhodesian trypanosomiasis developed thrombocytopenia with disseminated intravascular coagulation. Rats injected intraperitoneally with this strain of Trypanosoma rhodesiense consistently developed trypanosomiasis and severe thrombocytopenia without changes in hematocrit or concentration...
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Although experimental trypanosomiasis has been the subject of countless contributions to the literature, comparatively little has been written regarding the biological principles involved in the adaptation of the experimental infection to chemotherapeutic investigations. There have been numerous reports dealing with the more or less successful treatment of experimental trypanosomiasis beginning...
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By David Shepro, H. E. Sweetman, and H. B. Hechtman R EDUCED circulating platelets or thrombocytopenia is associated frequently with a propensity for petechial and purpuric hemorrhages. This observation has led to the concept that platelets support vascular endothelium and maintain vascular integrity by a mechanism separate from hemostasis or vascular repair. ‘ 6 Experimental thrombocytopenic a...
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The effects of subchronic trypanosomiasis upon immune responses were examined in Trypanosoma gambiense infection and in subcurative treatment of T. brucei- and T- equiperdum-infected mice. About 60% of the mice infected with T. gambiense developed a subchronic infection similar to human trypanosomiasis, characterized by the absence of circulating trypanosomes. The animals died between 1 and 12 ...
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Adult New Zealand white rabbits were experimentally infected with a parasitic African hemoflagellate, Trypanosoma congolense, and were subsequently tested for in vivo and in vitro aspects of cell-mediated immune function. Chronically infected rabbits were sensitized to mycobacterial protein and skin-tested with purified protein derivative; all infected animals demonstrated much milder skin-test...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1974
ISSN: 0021-9738
DOI: 10.1172/jci107684